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HEALTH Fertility problems could be caused by PCOS

PCOSPCOS among top causes of fertility problems – but it’s treatable

Almost everyday, I see or hear coverage of infertility in the media. It certainly seems more common nowadays, with many specialists proposing different reasons for this upswing. It is commonly agreed that people are now busier than ever and are starting their families later in life than before, and that this small delay may be affecting our fertility statistics.
I have met many couples experiencing fertility difficulties, and have seen the stress and worry it can inflict on a couple’s personal life and relationship.
Polycystic Ovary Syndrome (PCOS) affects between 5 per cent and 10 per cent of women in their reproductive years. It is considered one of the leading causes of subfertility in females. Subfertility describes a situation where a person less fertile than normal but still capable of reproducing. PCOS is treatable.

Cause
Believed to be genetic, the primary cause of PCOS is a resistance (or lack of responsiveness) of fat and muscle tissue and a converse oversensitivity of the ovaries to insulin.
Insulin is a hormone involved in regulating the amount of sugar in the bloodstream and its availability to the body as a fuel.
When a person is resistant to the effects of insulin, they start to produce more of it.
It is believed that higher levels of insulin stimulate the ovaries to produce more male sex hormones called androgens e.g. testosterone.
Increased levels of male sex hormones are believed to cause the main physical and hormonal abnormalities associated with PCOS.

Skin and hair

Male sex hormones stimulate increased sebum production in the hair follicle, making the skin more oily. Skin that is more greasy is more susceptible to acne. These hormones also over stimulate growth of facial and bodily hair, causing a condition known as hirsutism. They can also cause as thinning and loss of scalp hair in a similar pattern to male baldness.
Acne and increased hair growth are very common problems in PCOS, and treatment is usually quite straight forward. These include hair removal by waxing, shaving, bleaching, plucking, depilation and electrolysis. Although GPs like to be involved at every level of a condition, I tend to leave the plucking and bleaching to the beauticians! Doctors can prescribe hormonal treatments to reduce the effects of male sex hormones on the skin.

Metabolic problems
Resistance to insulin is associated with obesity, high blood pressure, type II diabetes and high colesterol levels, all of which are risk factors for cardiovascular disease. Women with untreated polycystic ovary syndrome are twice as likely to develop diabetes (including gestational diabetes in pregnancy) and almost three times as likely to have a stroke later in life due to a combination of the above conditions.
Medications can be prescribed to improve the body’s sensitivity to insulin and to treat coexisting issues, such as high blood pressure and cholesterol.
The universally sound objective of weight management, frequent exercise, healthy diet and avoiding smoking holds ever firm in this condition.

Menstrual and fertility problems
Due to elevated male sex hormones and insulin resistance, the finely controlled hormonal signalling system between the brain and ovary (hypothalamic-pituitary-ovarian axis) loses its normal cyclical function. Instead of one primary follicle (egg) developing in the ovary followed by rupture, egg release and menstruation each month, the ovary will develop many follicles (eggs) without rupture and release. Periods consequently become irregular, infrequent, patchy or disappear completely.
It is the lack of normal, predictable ovulation that makes conception and pregnancy more difficult in PCOS, although still possible to achieve. Treatment of subfertility involves complex hormonal treatments with drugs which promote and induce ovulation and are typically initiated by fertility experts. Results are good.
Even if fertility is not required, regulation of the menstrual cycle is important as it can reduce the risk of diabetes, cardiovascular disease and cancer of the womb later in life.

Diagnosis
A diagnosis of PCOS is made using specific criteria. These take into account the pattern of the menstrual cycle, the physical and chemical signs of excess male sex hormones, and an ultrasound scan of the ovaries.
If you are experiencing skin, menstrual or fertility problems in your reproductive years, your GP can assess you investigate things for you in a caring and confidential environment.
PCOS is a treatable condition which should not be left undiagnosed or untreated, not only for fertility purposes, but also to effectively prevent the longer-term health risks associated with the syndrome.

Dr Ronan Clancy is a GP at the newly opened Clancy Medical Practice, James street, Westport (www.westportgp.ie). He is in practice with Sarah Kavanagh, chartered physiotherapist.

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Gravity behind male pattern baldness?

Thehttps://i0.wp.com/www.personal.psu.edu/afr3/blogs/siowfa12/bald-head.jpg force of downward pull caused by the gravity on the scalp may be key contributor to the events leading to progressive hair loss in male pattern baldness, a new study claims.

The effects of gravity may explain the apparently paradoxical effects of testosterone in male pattern baldness, or androgenic alopecia (AGA), researchers said.

“The new theory’s unparallelled ability to explain even the details of the hair loss process and the formation of the pattern in AGA is apparent,” said Dr Emin Tuncay Ustuner, a plastic surgeon in Ankara, Turkey.

Ustuner’s “Gravity Theory” seeks to reconcile some puzzling observations related to the development and progression of AGA.

Balding areas of the scalp show increases in a potent form of testosterone called dihydrotestosterone (DHT), while drugs that block conversion of testosterone to DHT can slow hair loss.

In the scalp, DHT seems to cause hair follicles to become thinner. But in other areas of the body, such as the underarms and genital area, DHT and other male sex hormones promote thickening of hair follicles.

Ustuner believes, in youth, the scalp has sufficient fat tissue under the skin, and it is “capable of keeping itself well-hydrated,” buffering the pressure on hair follicles.

But with ageing, the skin and underlying (subcutaneous) fat become thinner, and the pressure on the hair follicles increases.

Testosterone contributes to thinning of the subcutaneous fat. In women, estrogen prevents thinning of these cushioning tissues, at least until menopause.

Ageing and testosterone-related changes create ‘vicious circle’ leading to hair loss as the cushion decreases, the hair follicle must strive against higher pressure, requiring more testosterone to achieve normal growth, researchers said.

This “local demand” leads to a buildup of DHT levels in the scalp, but not in the bloodstream. Rising DHT levels cause further erosion of the subcutaneous fat – creating a “vicious circle,” according to Ustuner.

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