Blog Archives

HEALTH Fertility problems could be caused by PCOS

PCOSPCOS among top causes of fertility problems – but it’s treatable

Almost everyday, I see or hear coverage of infertility in the media. It certainly seems more common nowadays, with many specialists proposing different reasons for this upswing. It is commonly agreed that people are now busier than ever and are starting their families later in life than before, and that this small delay may be affecting our fertility statistics.
I have met many couples experiencing fertility difficulties, and have seen the stress and worry it can inflict on a couple’s personal life and relationship.
Polycystic Ovary Syndrome (PCOS) affects between 5 per cent and 10 per cent of women in their reproductive years. It is considered one of the leading causes of subfertility in females. Subfertility describes a situation where a person less fertile than normal but still capable of reproducing. PCOS is treatable.

Cause
Believed to be genetic, the primary cause of PCOS is a resistance (or lack of responsiveness) of fat and muscle tissue and a converse oversensitivity of the ovaries to insulin.
Insulin is a hormone involved in regulating the amount of sugar in the bloodstream and its availability to the body as a fuel.
When a person is resistant to the effects of insulin, they start to produce more of it.
It is believed that higher levels of insulin stimulate the ovaries to produce more male sex hormones called androgens e.g. testosterone.
Increased levels of male sex hormones are believed to cause the main physical and hormonal abnormalities associated with PCOS.

Skin and hair

Male sex hormones stimulate increased sebum production in the hair follicle, making the skin more oily. Skin that is more greasy is more susceptible to acne. These hormones also over stimulate growth of facial and bodily hair, causing a condition known as hirsutism. They can also cause as thinning and loss of scalp hair in a similar pattern to male baldness.
Acne and increased hair growth are very common problems in PCOS, and treatment is usually quite straight forward. These include hair removal by waxing, shaving, bleaching, plucking, depilation and electrolysis. Although GPs like to be involved at every level of a condition, I tend to leave the plucking and bleaching to the beauticians! Doctors can prescribe hormonal treatments to reduce the effects of male sex hormones on the skin.

Metabolic problems
Resistance to insulin is associated with obesity, high blood pressure, type II diabetes and high colesterol levels, all of which are risk factors for cardiovascular disease. Women with untreated polycystic ovary syndrome are twice as likely to develop diabetes (including gestational diabetes in pregnancy) and almost three times as likely to have a stroke later in life due to a combination of the above conditions.
Medications can be prescribed to improve the body’s sensitivity to insulin and to treat coexisting issues, such as high blood pressure and cholesterol.
The universally sound objective of weight management, frequent exercise, healthy diet and avoiding smoking holds ever firm in this condition.

Menstrual and fertility problems
Due to elevated male sex hormones and insulin resistance, the finely controlled hormonal signalling system between the brain and ovary (hypothalamic-pituitary-ovarian axis) loses its normal cyclical function. Instead of one primary follicle (egg) developing in the ovary followed by rupture, egg release and menstruation each month, the ovary will develop many follicles (eggs) without rupture and release. Periods consequently become irregular, infrequent, patchy or disappear completely.
It is the lack of normal, predictable ovulation that makes conception and pregnancy more difficult in PCOS, although still possible to achieve. Treatment of subfertility involves complex hormonal treatments with drugs which promote and induce ovulation and are typically initiated by fertility experts. Results are good.
Even if fertility is not required, regulation of the menstrual cycle is important as it can reduce the risk of diabetes, cardiovascular disease and cancer of the womb later in life.

Diagnosis
A diagnosis of PCOS is made using specific criteria. These take into account the pattern of the menstrual cycle, the physical and chemical signs of excess male sex hormones, and an ultrasound scan of the ovaries.
If you are experiencing skin, menstrual or fertility problems in your reproductive years, your GP can assess you investigate things for you in a caring and confidential environment.
PCOS is a treatable condition which should not be left undiagnosed or untreated, not only for fertility purposes, but also to effectively prevent the longer-term health risks associated with the syndrome.

Dr Ronan Clancy is a GP at the newly opened Clancy Medical Practice, James street, Westport (www.westportgp.ie). He is in practice with Sarah Kavanagh, chartered physiotherapist.

Advertisements

Women with weak thyroid more likely to have autistic children

PregnantPregnant women who don’t produce enough thyroid hormone are nearly four times likelier to give birth to autistic children than their healthy peers, a new study has claimed. Scientists from the Houston Methodist Neurological Institute in US and Erasmus Medical Centre in Rotterdam, Netherlands studied more than 4,000 Dutch mothers and their children. Their results support the growing view that autism spectrum disorders can be caused by a lack of maternal thyroid hormone, which past studies have shown is crucial to the migration of foetal brain cells during embryo development.

“It is increasingly apparent to us that autism is caused by environmental factors in most cases, not by genetics. That gives me hope that prevention is possible,” said lead author Gustavo Roman, a neurologist and neuroepidemiologist who directs the Nantz National Alzheimer Center. The researchers also found that autistic children had more pronounced symptoms if their mothers were severely deficient for T4, also called thyroxine. Mild T4 deficiencies in mothers produced an insignificant increase in autistic children’s symptoms. The most common cause of thyroid hormone deficiency is a lack of dietary iodine – because both the thyroid hormones, T3 and T4, contain that element.

The present work was based on the Generation R Study, conducted by Erasmus Medical Centre doctors and social scientists, in which thousands of pregnant women were voluntarily enrolled between 2002 and 2006. Researchers identified 80 “probable autistic children” from a population of 4,039. Around 159 mothers were identified as being severely T4 deficient (defined as having 5 per cent or less of normal T4, but producing a normal amount of thyroid stimulating hormone), and 136 were identified as mildly T4 deficient.

The researchers found a weak association between mild T4 deficiency and the likelihood of producing an autistic child, but a strong association between severe T4 deficiency and autism (3.89 more likely, as compared with mothers with normal thyroid hormone). The study presents a troubling correlation, but it does not prove that the thyroid function of expecting mothers causes autism in their children, researchers said. The study will be published in the journal Annals of Neurology.

%d bloggers like this: